허혈성 뇌졸중 유발 백서에서 수증운동이 하지근 및 대뇌의 HSP 70 발현에 미치는 영향

Effects of Swimming Exercise on Hind-Limb Muscles and HSP 70 Expression in the Ischemic Stroke Model of Rats

Ischemic stroke results from a transient or permanent reduction in cerebral blood flow that is restricted to the territory of a major brain artery. Thus, this study was performed to examine (1) the effects of swimming exercise on the improvement of muscle atrophy, and (2) exercise and HSP 70 expression in anischemic stroke model induced by middle cerebral artery occlusion. The results of this study were as follows: One week after ischemic stroke was induced, changes appeared in the muscle weight of the gastrocnemius muscle due to muscle atrophy in the affected side. Group Ⅱ showed statistically significant difference from group Ⅲ eight weeks after ischemic stroke was induced. (p＜.05). One week and eight weeks after ischemic stroke was induced there was significant decrease in the relative muscle weight of the gastrocnemius muscle in each group except Group Ⅳ, while there was statistically significant in crease in group Ⅱ eight weeks after ischemic stroke was induced, compared to group Ⅲ (p＜.05). For neurologic exercise behavior tests, Group Ⅱ generally had the highest score, compared to other groups. In immunohistochemical observations, Group Ⅱ showed a decrease in HSP 70. The above results suggest that swimming exercise improved muscle atrophy, changed the HSP 70 expression of ischemic stroke in rats, and contributed to the improvement of exercise function.