고빈도 및 저빈도 전침이 당뇨쥐의 혈당과 면역글로불린 G 및 콜레스테롤 농도에 미치는 영향

The Effect of Electrical Acupuncture of High and Low Frequencies on Glucose, lmmunoglobulin G and Cholesterol in Diabetic Rats

Electrical acupuncture has been shown to induce hypoglycemic effect in streptozotocin diabetic rats. The Zusanli acupoints have been widely used in traditional Chinese medicine to relieve symptoms of dia-betes mellitus. But, the effects of electrical acupuncture stimulation of different frequencies are still unclear. We designed an experiment to investigate the effect of electrical acupuncture of high (100 ㎐) and low (2 ㎐) frequencies on Zusanli acupoint for 15 minutes in streptozotocin diabetic rats. They were divided into 4 groups, high frequency electrical acupuncture (HFEA group, n=5), low frequency electrical acupuncture (LFEA group, n=5), without any treatment (control group, n=5) and normal group (n=5) After 2 weeks of treatment, the HFEA and LFEA groups had a significantly decreased glucose concen-tration in serum in comparison to the control group. Additionally, the HFEA group had a significantly de-creased glucose concentration in serum compared with the LFEA group. Both the HFEA and LFEA groups had a significant1y decreased Immunoglobulin G concentration in serum compared with control group. The LFEA and control groups had a significant1y increased cholesterol concentration in serum compared with the normal group, but the HFEA did not have a significantly increased cholesterol concentration. Thus we suggest that electrical acupuncture stimulation at the Zusanli acupoints is effect-tive on hypoglycemic effect and immune function. Overall，the therapeutic effects of electrical acupuncture at 100 ㎐ was better than effects at 2 ㎐.