화장품 소재로서 더덕과 발효더덕 추출물의 피부관련 생리활성 비교탐색

A Comparative Study of the Physiological Activities of Skin between Codonopsis lanceolata and Fermented C. lanceolata Extracts as Cosmetic Ingredient

This study examined the physiological activities of the skin through utilization of Codonopsis lanceolata and Fermented C. lanceolata extracts to determine if they could be used as cosmetic ingredients. The following results were obtained: According to a measurement of polyphenols and flavonoid content, 32.7±0.88 ㎎/g of polyphenols and 1.41±0.31 ㎎/g of flavonoid were observed in fermented C. lanceolata extract. In terms of the DPPH radical scavenging activity, 41.11±0.77 μg/mL was observed at 1000 μg/mL of fermented C. lanceolata extract. In terms of the nitric oxide scavenging activity as well, 80.21±0.90 μg/mL was detected at 1500 μg/mL. According to measurement of tyrosinase inhibition activity, 7.33±2.60% was found at 100 μg/mL. Therefore, the fermented C. lanceolata extract was higher than the C. lanceolata extract in terms of tyrosinase inhibition activity. According to measurement of the antimicrobial effect on skin bacteria such as P. acnes, S. aureus and S. epidermidis, in addition, a clear zone was observed with 9.580 ±0.39 8.10±0.42 and 8.00±0.14 at 5 mg/disc. This shows that the C. lanceolata extract was greater than the fermented C. lanceolata extract in terms of antimicrobial effect. According to measurement of toxicity on the B16F10 melanoma cell, survival rates were fairly low at some concentration levels, but they were not severe enough to cause toxicity. Based on the results above, this study has confirmed that fermented C. lanceolata extract can be utilized as a cosmetic ingredient because it is higher in physiological activity than the C. lanceolata extract.