로즈마리 추출물의 화장품 생리활성 및 세포 독성 연구

Study of Cosmetic Biological Activity and Cytotoxicity on Rosemary Extract

This study of the antioxidant effect of rosemary extract and anti-inflammatory, anti-bacterial effect to find out, it is harmless to the human body, and antioxidants for aging and skin whitening evaluate the effect is higher. Thus, the DPPH radical scavenging antioxidant effect and ABTS radical scavenging activity and polyphenol, flavonoid content was measured, anti-inflammatory, antibacterial, cytotoxic effects were measured. As a result, According to the measurement of the DPPH radical scavenging activity, as the concentration of rosemary extract increased in a concentration-dependent. And an analysis of the ABTS radical scavenging activity of rosemary extract, it increased in a concentration-dependent. The total polyphenol content in 1㎎/㎖ was ±0.056㎎(GAE)/100g while flavonoid content was 175.1±0.020㎎(GAE)/100g. The results, it was verified that rosemary has strong anti-oxidant effects. The extract also revealed strong anti-microbial effects against Propionibacterium acne and Staphylococcus aureus. According to analysis of the vitality of mouse macrophages in rosemary extract, high cell vitality was observed at low concentrations. In this study, therefore, the availability of rosemary extract as a cosmetics material was confirmed. It is expected that the results of the study would be useful as basic data in the manufacture of cosmetics and cosmetics-related studies.