토코페롤의 대장암세포 성장, 침윤, 부착에 대한 억제 효과

Inhibitory Effects of Tocopherols on Growth, Invasion, and Attachment in Human Colon Cancer Cells

The aim of the study was to investigate the inhibitory effects of different forms of tocopherols (T) on cell growth, invasion, and attachment in HCT116 human colon cancer cells. Treatment with γ-T and δ-T significantly inhibited cell growth (by 58.1-97.8% at the concentrations of 50-100 μM), invasion (by 49.4-87.0% at the concentrations of 20-80 μM), and attachment (by 28.2-75.4% at the concentrations of 50-100 μM). α-T, however, did not exhibit such inhibitory activities. δ-T was more active than γ-T in inhibiting cell attachment at the effective concentrations (p<0.05). These studies demonstrated the inhibitory activities of γ-T and δ-T against cell growth, invasion and attachment in HCT116 cells. More studies are needed in order to elucidate detailed mechanisms for the inhibitory action of γ-T and δ-T.