『素問玄機原病式』에 기재된 中風의 火熱 病因論에 대한 저체온요법을 통한 실험적 고찰

An experimental study of HwaYul(火熱) theory on the 『SoMunHyunKiWonByungSik(素問玄機原病式)』

In Oriental medicine, different suggestions regarding how cerebrovascular accident(CVA) may develop have been offered by several physicians. In Jin(金)Yuan(元) dynasty, Liu Wan Su(劉完素) asserted that CVA was not developed by external PungSa(風邪) but internal HwaYul, which was noted in the 『SoMunHyunKiWonByungSik』. To verify experimentally Liu's HwaYul theory in rats, normothermic control group (37℃) and hypothermic test group (32℃) were subjected to transient middle cerebral artery occlusion(MCAO) of 1hour. In 7days after MCAO, the rats were sacrified and the volume of infarct and the size of edema were measured. The present findings expand our understanding of the pathophysiology as to the CVA which is related to the HwaYul theory.