반코마이신의 약물동태학적 모델링과 시뮬레이션의 향상을 위한 분석오차

Assay Error for Improved Pharmacokinetic Modeling and Simulation of Vancomycin

The purpose of this study was to determine the influence of assay error for improved pharmacokinetic mod- eling and simulation of vancomycin on the Bayesian and nonlinear least squares regression analysis in 24 Korean gastric ncer patients. Vancomycin 1.0 g was administered intravenously over 1 hr every 12 hr. Three specimens were collected at 72 hr after the first dose from all patients at the following times, at 0.5 hr before regularly scheduled sion, at 0.5 hr and 2 hr after the end of 1 hr infusion. Serum vancomycin levels were analyzed by fluorescence polarization munoassay technique with TDX-FLX. The standard deviation (SD) of the assay over its working range had been determined at the serum vancomycin concentrations of 0, 20, 40, 60, 80 and 120 µg/ml in quadruplicate. The polynomial equation of van- comycin assay error was found to be SD (µg/ml)=0.0224+0.0540C+0.00173C2 (R 2=0.935). There were differences in the influence of weight with vancomycin assay error on pharmacokinetic rameters of vancomycin using the nonlinear least squares regression analysis but there were no differences on the Bayesian analysis. This polynomial equation can be used to improve the precision of fitting of pharmacokinetic models to optimize the process of model simulation both for population and for individualized pharmacokinetic models. The result suggests the improvement of dosage regimens for the better and safer care of patients receiving vancomycin.