학술저널
크로만-2-카르복실산 N-아릴알킬아마이드 유도체의 구조-활성관계
Structure-Activity Relationship of Chroman-2-carboxylic Acid N-Arylalkylamide Derivatives
- 대한약학회
- 약학회지
- 제57권 제6호 (2013년)
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2013.12426 - 431 (6 pages)
- 10
In our previous studies, 6-hydroxy-7-methoxychroman-2-carboxylic acid N-phenylamide (KL-1156) was iden- tified as a good inhibitor of nuclear factor-κB (NF-κB) activation. In continuation of our study, we describe the structure- activity relationship of chroman derivatives containing N-arylalkyl groups and their NF-κB inhibitory activities. In addition, inhibitory effects of cell proliferation are evaluated against human cancer cell lines (NCI-H23 and PC-3). The most active compounds 3i and 3j contained diphenylethyl and diphenylpropyl side chain on amide nitrogen.
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