배양된 기도 상피세포에서 종양괴사인자에 의한 IκB의 분해와 NF-κB p65의 핵으로의 이동에 미치는 실리비닌과 레스베라트롤의 영향
Effects of Silibinin and Resveratrol on Degradation of IκB and Translocation of NF-κB p65 Induced by Tumor Necrosis Factor-α in Cultured Airway Epithelial Cells
- 대한약학회
- 약학회지
- 제58권 제1호 (2014년)
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2014.021 - 6 (6 pages)
- 49
We examined whether silibinin and resveratrol affect airway mucin production, degradation of IκB and trans- location of NF-κB p65 induced by TNF-α in NCI-H292 cells. Cells were pretreated with each agent for 30 min and then stim-ulated with TNF-α for 24 h or the indicated periods. The two compounds suppressed TNF-α-induced airway mucin production, degradation of IκB and translocation of NF-κB p65. This result suggests that silibinin and resveratrol can reg-ulate the production of mucin induced by TNF-α through the inactivation of NF-κB pathway in airway epithelial cells.
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