학술저널
새로운 옥사졸리디논계 항균제 LCB01-0371에 대한 Enterococcus faecalis의 내성 기전
Resistance Mechanism of Enterococcus faecalis to LCB01-0371, a New Oxazolidinone
- 대한약학회
- 약학회지
- 제58권 제1호 (2014년)
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2014.027 - 11 (5 pages)
- 24
To study the resistance mechanism of E. faecalis to LCB01-0371, several resistant mutants to LCB01-0371 or linezolid were isolated by step-wise selection. The frequency of spontaneous mutations resistant to LCB01-0371 was lower than that of linezolid in E. faecalis. The genetic variations in resistant mutants were analyzed by DNA sequencing of domain V of 23S rRNA in each mutant. The first-step mutant to LCB01-0371 had a G2576T point mutation in V domain of 23S rRNA. However, no resistant mutant to LCB01-0371 was isolated in second-step mutant selection.
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