호장으로부터 분리한 스틸벤류의 Nitric Oxide 저해활성

Inhibition of Nitric Oxide Production by Stilbenes from Polygonum cuspidatum

Polygonum cuspidatum which is widely distributed in Korea has been used as treatments of dermatitis, gon- orrhea, favus athlete's foot, hyperlipidemia and inflammation in traditional medicine. We examined anti-oxidant and anti-inflammatory activity by measuring DPPH radical scavenging activity and the inhibition of IFN-γ and LPS-induced NO pro-duction in RAW 264.7 murine macrophage cells. We isolated and characterized resveratrol (1), trans-resveratrol 3-O-β-D-glucopyranoside (2). Compounds 1 and 2 showed potent activities compared with L-NMMA (N G -monomethyl-L-arginine).These results suggested that the stilbene compounds isolated from Polygonum uspidatum might be used as antiin-flammatory agents.