분말약품 혼합의 균일성에 관한 연구

A Study on the Homogeneity of Powder Mixture

The effects of the particle size on the homogeneity of mixing and segregation of caffeine-lactose (1:99) mixture were studied. Using the two kinds of caffeine, milled and unmilled caffeine, V-type blender, the degree of mixing according to the particle size was predicted and the experiment on the change of rnixedness by mixing time was carried out by the method derived from mixing index theory by Poole et al. and Hersey. the results could be summarized as follows:(l) The homogeneity of mixing was greatly affected by the particle size and the particle size should be reduced to the adequate level to attain the desirable mixedness. (2) The homogeneity was not proportional to the mixing time and optimum mixing time for caffeine-lactose was about 10 minutes. (3) Segregation tendency was increased by the particle size increase and greatly affected by the flow time in the segregation cell.