Sulpiride의 Polymorphism 및 그 약제학적 연구(II) Polymorph 상호간의 Transformation Kinetics

Polymorphism of Sulpiride and its Pharmaceutical Applications(II) Transformation Kinetics of Sulpiride Polymorphs

The transformation kinetics between polymorphs of sulpiride and the effect of additives on the transformation kinetics were studied. The results could be summarized as follows. 1. Transformation kinetics of the polymorph form I to form II in water suspension was first order type and transformation rate constant at 25oC is 2.61 X 10-2min-1, the half life of form I was about 27 minutes and the activation energy for transformation was 21.35Kcal/mole. 2. Glycerine and coloring agents increased the rate of transformation. In the case of polysorbate 80, the rate constant increased in proportion to the concentration of polysorbate 80. Simple syrup showed no effect on transformation kinetics.