학술저널
Studies on the Anti-inflammatory Agents. Synthesis of Carboxamides and Their Anti-inflammatory Activity
- 대한약학회
- 약학회지
- 제21권 제4호 (1977년)
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1977.12173 - 176 (4 pages)
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Four compounds, N-(2,3-dimethylphenyl)benzamide, N-(3-trifluoromethylphenyl)benzamide, N-(2,3-dimethylphenyl)cinnamamide and N-(3-trifluoromethylphenyl)cinnamamide, were synthesized and evaluated their activity by the method of the inhibitory effect on the carrageenin-induced rat paw edema, compared with phenylbutazone. All of these exhibited anti-inflammatory activity, and N-(2,3-dimethylphenyl)benzamide exhibited 45.7% edema inhibition vs. control when 100mg/kg of dosage was administered, whereas phenylbutazone, 51.4% for 50mg/kg
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