Nitrofuran계 의약품의 안전성에 관한 착물화학적 연구(I) Mo-thiol착물에 의한 Nitrofurazone의 촉매환원

Coordination Chemical Approach to the Safety of Nitrofuran Drugs I. Reduction of Nitrofurazone Catalyzed by Molybdothiol Complexes

In the presence of dithionite, two kinds of molybdothiol complexes, particularly isolated Mo-cysteine complexes, used as models for xanthine oxidase or aldehyde oxidase exhibited catalytic activity on the reduction of nitrofurazone to its amino derivative. Of the two Mo-cysteine complexes, the activity of oxo-bridged one was apparently greater than that of sulfido-bridged one. The promoting effect was hardly shown by added cofactors or their replacements of the enzymes. The catalyzed reduction is considered to take place by consecutive direct two-electron transfer mechanism from catalytically active reduced form of the molybdothiol complexes to nitrofurazone and the probable intermediates.