학술저널
히단토인 유도체 형성에 있어서 alpha-Diethaylaminoacetophenone의 탈이반응
Elimination Reaction of alpha-Diethaylaminoacetophenone in the Formation of Hydantoin Derivatives
- 대한약학회
- 약학회지
- 제22권 제4호 (1978년)
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1978.12215 - 218 (4 pages)
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It is known that hydantoin derivative can be synthesized according to the method of Bucherer-Bergs, which employs the interaction of the carbonyl compounds with potassium cyanide and ammonium carbonate in dilute alcohol solution. In a converting study of alpha-diethylaminoacetophenone with KCN and (NH4)2CO3 to hydantoin, the attempted 5-diethylaminomethyl-5-phenylhydantoin was not formed. In this reaction diethylaminomethyl group was unexpectedly eliminated and 5-phenylhydantoin was obtained, instead of the anticipated compound.
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