학술저널
소염진통제에 관한 연구 Arylpropionic acid 류의 합성 및 항부종시험
Studies on the Synthesis of Arylpropionic Acids and their Antiinflammatory Activity
- 대한약학회
- 약학회지
- 제23권 제2호 (1979년)
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1979.06119 - 124 (6 pages)
- 2
Eight derivatives of arylpropionic acid, arylcarbonylpropionic acid, and arylhydroxybutyric acid were synthesized and their structures were elucidated on the basis of elemental analysis and spectral data. Also their antiinflammatory activities were evaluated by the method of the inhibitory effect on the carrageenin-induced rat paw edema and compared with phenylbutazone. Compound (I) exhibited 59% edema inhibition vs control when 100mg/kg, was orally administered, whereas phenylbutazone showed 57.8% for 50mg/kg.
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