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L(+)-Glutamic Acid 유도체의 합성(II)

Studies on the Synthesis of L(+)-Glutamic Acid Derivatives(II)

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In the formation of L(+)-glutamine from L(+)-glutamic acid-5-hydrazide, large amount of Raney-Ni was effective under normal pressure but hydrogenation or amonolysis of ester under pressure was useless. Preparation of glutamine with alpha-ketoglutaric acid (by way of 1,4,5,6-tetrahydro-6-oxo-3-pyridazine carboxylic acid)is intersting but not so efficient in yield.

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