지리오갈피나무 엽 신 배당체 Chiisanoside의 생물학적 효능

The Biological Activity of a New Glycoside, Chiisanoside from Acanthopanax chiisanensis Nakai Leaves

A new glycoside was isolated from Acanthopanax chiisanensis Nakai (Araliaceae) leaves and its biological activity was investigated. The new glycoside was tentatively assigned the structure of Asecotriterpenoid glycoside, C48H76O19, m.p. 208~209o and named chiisanoside. Chiisanoside exhibited non-toxic effects and significant antihistaminic activity. It was found that chiisanoside showed the antidiabetic activity against epinehrine-and alloxan-induced diabetes, decreased the toxicity of LD50 by ephedrine hydrochloride and promoted the elimination of chloramphenicol from blood. Chiisanoside also increased the survival rate in rats intoxicated by carbon tetrachloride from death and led to re-establishment of normal enzymatic function. In the histopathological studies, chiisanoside improved fatty degeneration and parenchymal cell necrosis of the liver induced by carbon tetrachloride in rats.