학술저널
Riboflavin과 Barbiturate와의 분자간 상호작용
Molecular Interaction of Riboflavin and Barbiturates
- 대한약학회
- 약학회지
- 제25권 제4호 (1981년)
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1981.12167 - 173 (7 pages)
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Spectroscopic investigation has been carried out to know the binding mechanism of riboflavin with barbiturates, such as pbenobarbital and amobarbital in chloroform solution by using infrared and nuclear magnetic resonance spectra. Phenobarbital and isoalloxazine form a 1:1 cyclic hydrogen bonded dimer through the 3-N imino and the 2-C carbonyl groups of the isoalloxazine ring of the latter, and the 1-N(or 3-N) imino and the 2-C carbonyl groups of the pyrimidine ring of the former. Amobarbital and riboflavin form a 1:1 cyclic hydrogen bonded dimer by the same mode of phenobarbital.
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