학술저널
s-Triazine의 Ring Transformation에 의한 5-FU의 합성
Synthesis of 5-Fluorouracil by Ring Transformation of s-Triazine
- 대한약학회
- 약학회지
- 제26권 제1호 (1982년)
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1982.0425 - 27 (3 pages)
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We had reported that s-triazine can readily be converted into the corresponding 5-substituted pyrimidine. In order to develop new synthetic method of 5-fluorouracil, we tried to replace eliminating fragment, 1, 3-dimethylurea, by fluoroacetamide, which was expected to undergo nucleophilic attack by proton extraction of both alpha-hydrogen and aminohydrogen by lithium diisopropylamide (LDA). We found that 5-fluorouracil could be transformed from s-triazine under strong base condition like LDA as well as other 5-substituted pyrimidines.
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