학술저널
Epsilon-N-[(2-Chloroethyl) nitrosocarbamoyl]-L-lysine의 합성
Preparation of epsilon-N-[(2-Chloroethyl) nitrosocarbamoyl]-L-lysine
- 대한약학회
- 약학회지
- 제27권 제2호 (1983년)
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1983.06177 - 179 (3 pages)
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A copper complex of epsilon-N-[(2-chloroethyl)carbamoyl]-L-lysine was prepared by the treatment of the L-lysine copper complex with 2-chloroethyl isocyanate in cold water. Within the L-lysine copper complex molecule, the alpha-amino and carboxyl groups are bounded to Cu2+, but the epsilon-amino group is free and can react with carbamoylating agents. A potential antitumor agent, epsilon-N-[(2-chloroethyl) nitrosocarbamoyl]-L-lysine was synthesized by nitrosation of this copper complex with Na N02 in anhydrous formic acid, followed by the passage of H2S gas.
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