학술저널
DMSO-Oxalyl Chloride에 의한 당의 산화
DMSO-Oxalyl Chloride for the Oxidation of Carbohydrates
- 대한약학회
- 약학회지
- 제27권 제2호 (1983년)
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1983.06181 - 184 (4 pages)
- 14
DMSO-oxalyl chloride at low temperature in methylene chloride reacted with isolated secondary hydroxyl groups in some monosaccharides to give alkoxysulfonium salts, convertible to carbonyls in high yields upon addition of triethylamine. And 1,2:5,6-di-O-isopropylidene-alpha-D-allofuranose which is the key intermediate in the synthesis of 3-0-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranosyl bromide, was also obtained by oxidizing 1, 2:5, 6-di-O-isopropylidene-alpha-D-glucofuranose with the oxidizing reagent, followed by reduction with sodium borohydride.
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