학술저널
alpha-Piperidinoacetophenone의 Hydantoin 형성 반응
Bucherer Berg''s Reaction of alpha-Piperidinoacetophenone in the Formation of Hydantoin
- 대한약학회
- 약학회지
- 제27권 제3호 (1983년)
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1983.09245 - 247 (3 pages)
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In Bucherer-Berg''s reaction of alpha-piperidinoacetophenone with KCN and (NH4)2CO3 in dilute alcohol solution to form hydantoin, the expected 5-phenyl-5-piperidinomethylhydantoin was not formed. In this reaction alpha-piperidinomethyl group was eliminated and 5-phenylhydantoin was obtained. According to GC/MS study of the reaction mixture, the one of the chromatograms, which has mole peak 124, was identified as alpha-piperidinoacetonitrile. Under the pressurized condition, diphenylhydantil was obtained instead of 5-phenylhydantoin, which might have dimerized to the former
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