학술저널
약물과 생체고분자간의 상호작용(VI) Nalidixic Acid 및 Probenecid와 우혈청 단백간의 결합에 관한 연구
Drug-Biomacromolecule Interaction (VI) Binding of Nalidixic Acid and Probenecid to Bovine Serum Albumin
- 대한약학회
- 약학회지
- 제27권 제4호 (1983년)
-
1983.12257 - 261 (5 pages)
- 4
Binding of nalidixic acid which is used primarily in the treatment of urinary infection and probenecid which is used as a uricosuric agent to bovine serum albumin were studied using difference spectrophotometric method. 2-(4''-Hydroxybenzeneazo) benzoic acid as a .spectrophotometric probe was used for measuring the binding of nalidixic acid and probenecid to bovine serum albumin. The association constants of nalidixic acid and probenecid were 1.58 X 104 M-1 and 1.70 X 104 M-1, respectively
(0)
(0)