학술저널
s-Triazine의 Ring Transfromation에 의한 Pyrimidopyrimidine의 합성
Synthesis of Pyrimidopyrimidine by Ring Transformation of s-Triazine
- 대한약학회
- 약학회지
- 제28권 제2호 (1984년)
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1984.0497 - 100 (4 pages)
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We have investigated the feasibility of using cyclic ambident nucleophiles in s-triazine ring transformation reaction and found that they can replace the N1-C2-N3 fragment of s-triazine directly in basic conditions, yielding the corresponding bicyclic products. In this paper, we described the reaction and mechanistic aspects of s-triazine to pyrimidopyrimidine transformation by 6-aminouracil derivatives. This type of ring transformation is supposed to be first attempt that deals with the successful s-triazine to bicyclic heterocycle transformation.
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