학술저널
인도메타신의 용해도에 미치는 계면 활성제의 영향
Effect of Surfactants on the Solubility Properties of Indomethacin
- 대한약학회
- 약학회지
- 제28권 제3호 (1984년)
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1984.06161 - 167 (7 pages)
- 7
To improve the solubility properties of indomethacin, a poorly water-soluble drug, some attempts were made with surfactants, such as sodium deoxycholate, sodium laurylsulfate and polysorbate-80. The enhancement effect in solubility was found to be due to the micellar solubilization and dependent on the concentration of surfactants, pH and temperature. The mechanism of interaction was suggested to be attributed to the formation of mixed micelles between the drug and solubilizers.
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