흰쥐에서 alpha-Adrenaline 효능 약물등이 피마자유 유발설사에 미치는 영향

Effects of alpha-Adrenergic Drugs on Castor Oil Induced Diarrhea in Rats

The effect of lofexidine, clonidine, and other drugs on castor oil induced diarrhea in rats was investigated. Castor oil was administered orally and drugs were administered intraperitoneally. The results were as follows. 1. Lofexidine(0.1-3mcmol/kg) blocked dose dependently castor oil-induced diarrhea like clonidine, but its potency was weaker than that of clonidine. 2. Yohimbine (1-10mcmol/kg) antagonized the antidiarrheal action of lofexidine and clonidine. 3. Prazosin (3-30mcmol/kg) did not antagonize the antidiarrheal action of lofexidine and clonidine. 4. Metoclopramide, bromocriptine mesylate, and nadolol did not affect antidiarrheal action of lofexidine significantly. 5. Loperamid prolonged the antidiarrheal action of lofexidine.