학술저널
Cinnarizine을 Propranolol이나 Metoprolol과 병용할 때의 혈압 강하 효과에 관한 약리학적 연구(I) 혈압 변화에 대한 효과
Pharmacological Studies on the Antihypertensive Effects of Cinnarizine Coadministered with Propranolol or Metoprolol(I). Effects on Blood Pressure Change
- 대한약학회
- 약학회지
- 제28권 제5호 (1984년)
-
1984.10249 - 256 (8 pages)
- 5
The effects of Ca2+-antagonist, cinnarizine, on the antihypertensive effects of propranolol and metoprolol were investigated in normal cat (i.v.) and SHR (p.o.). Cinnarizine increased the antihypertensive effect of propranolol, but not of metoprolol. It inhibited the heart rate decreasing effects of propranolol and metoprolol slightly. It decreased the norepinephrine-induced blood pressure increasing effect and isoproterenol-induced blood pressure decreasing effect when coadministered with metoprolol orally for 4 weeks in SHRs.
(0)
(0)