Cinnarizine을 Propranolol이나 Metoprolol과 병용할 때의 혈압강하효과에 관한 약리학적 연구(III) 생리학적 변화에 대한 영향

Pharmacological Studies on the Antihypertensive Effects of Cinnarizine Coadministered with Propranolol or Metoprolol(III). Effects on Biochemical Changes

The effects of cinnarizine, Ca2+-antagonist, on the antihypertensive effect of coadministered beta-blockers, propranolol and metoprolol, were investigated in SHR. Drugs were coadministered orally for 4 weeks. Hemodynamic and biochemical changes induced by above drugs were determined to elucidate their mechanism of action. a) Cardiohypertropy of SHR was significantly improved by the treatment of beta-blockers as well as combination with cinnarizine and beta-blockers. b) Mg2+-contents were increased in ventricle and decreased in plasma and aorta in all of the groups, especially in the group of propranolol with cinnarizine. c) c-GMP contents in ventricle were increased when cinnarizine was coadministered with propranolol, and c-GMP contents in aorta were increased when cinnarizine was coadministered with metoprolol, camparing with propranolol or metoprolol alone-treated group. d) Plasma renin activity appeared to be increased in cinnarizine treated alone, but reduced by combination with beta-blockers. e) Triglycerides and Na+ contents in serum were decreased in the group of metoprolol with cinnarizine, comparing with metoprolol alone-treated group. Increased K+ and Ca2+ excretions in urine by beta-blockers were inhibited by cinnarizine, so Na+/K+ excretion ratios were increased. Diuretic effects was showed in metoprolol alone treated group, but reduced when coadministered with cinnarizine.