학술저널
Imidazo-thiazole 쯔비터 이온 유도체의 합성과 반응성
Synthesis and Reactivity of Zwitterionic Bicyclic Imidazo-thiazole Derivatives
- 대한약학회
- 약학회지
- 제29권 제1호 (1985년)
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1985.0239 - 42 (4 pages)
- 10
Betaines of bicyclic imidazo-thiazoles were synthesized by the reaction of electrophiles such as methyl isocyanate, methyl isothiocyanate, allyl isothiocyanate and ketene with 3-methyl and 3-phenyl-5,6-dihydroimidazo[2,1-b]thiazole. In this reaction, the methyl group which was substituted at 3-position increased the yields of the products in comparison with those from phenyl group substituted substrates. Also, the betaines reacted with methyl iodide to give imidazo-thiazolium salts which were unstable at high temperature and converted the quaternary ammonium salts of original biheterocycles.
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