수종 식물성 다당류의 사염화탄소 및 D-Galactosamine 유발 급성 간손상 보호작용

Protective Effects of Some Phytobased Polysaccharides on the Acute Hepatic Damages of ICR-Mice Induced by the Administration of Carbon Tetrachloride and D-Galactosamine

Polysaccharides obtained from Sappan Lignum, Mori Radicis Cortex and Olibanum were examined for their liver protective effects against carbon tetrachloride- and D-galactosamine intoxication in ICR-mice. Hexobarbital sleeping time and serum transaminases (S-GOT and S-GPT) were measured as parameters for the evaluation of liver protective effects. All polysaccharides tested in this experiment showed remarkable positive effects on the prevention of hepatic intoxication with carbon tetrachloride- and D-galactosamine. Much better liver protective effects of polysaccharides were observed in D-galactosamine-liver injuries than in carbon tetrachloride-injuries.