학술저널
클로람페니콜의 면역독성에 미치는 식이지방의 영향
Effect of Dietary Fat on the Immunotoxicity of Chloramphenicol
- 대한약학회
- 약학회지
- 제29권 제2호 (1985년)
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1985.0455 - 61 (7 pages)
- 10
The effect of dietary fat on the immunotoxicity of chloramphenicol was investigated in mice, sensitized and challenged with sheep red blood cells. Chloramphenicol suppressed more cell-mediated immunity than humoral immunity. The saturated fat diet elevated humoral and cell-mediated immunotoxicity, whereas the unsaturated fat diet decreased humoral immunotoxicity, but elevated cell-mediated immunotoxicity of chloramphenicol. Especially, the normal diet in saturated and unsaturated fat restored immunosuppressive effect of chloramphenicol compared to the saturated fat diet and the unsaturated fat diet.
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