괄루성 엑기스가 백서에서의 Alloxan 유발 당뇨에 미치는 영향

Antidiabetogenic Activity of Trichosanthes kirilowii on the Alloxan-treated Mouse

In order to investigate the antidiabetogenic activity of T. kirilowii on the alloxan-treated mice, the effects of the oral administration of the methanol extract on the blood glucose, the survival rate and the histological changes of the Langerhans'' islet were observed. The blood glucose was reached at the highest levels of 265.03 +/- 15.07 and 186.41 +/- 10.16mg/dl at 30 min after alloxan injection, and at the lowest levels of 43.35 +/- 5.28 at 4 hour and 20.40 +/- 3.26mg/dl at 10 hour in experimental and control group, respectively. 57.15% of the experimental group and 4.2% of the control group were survived more than 24 hours. The life spans of the mice, which were dead within 24 hours, were 631.45 +/- 60.17 for the experimental group and 414.60 +/- 36.24 min for the control group. The mice from the control group, which were dead within 10 hours, showed totally necrotized alpha- and beta-cells. However, 3 of the 10 mice from the experimental group, which were survived until 24 hours, showed a normal histological feature of the Langerhans' islet.