시판 유산균 및 낙산균제제의 항결핵제 및 항생물질에 대한 감수성과 내성

Susceptibility and Resistance of Lactobacilli and Clostridia in the Commercially Available Preparations to Antituberculosis Agents and Antibiotics

To investigate the susceptibility and resistance in case of simultaneous administrations of Lactobacilli and Clostridia preparations with antituberculosis agents and antibiotics, five strains of Lactobacilli, i.e., Lactobacillus bulgaricus, L. casei, L. helveticus, L. acidophilus, L. sporogenes and Clostridium butyricum were isolated from commercially available preparations. Minimal inhibitory concentrations(MIC) of nine antituberculosis agents and 21 antibiotics against these strains were determined. The results showed that these strains were very sensitive only to rifampicin among antituberculosis agents, and sensitive to other antibiotics. Since the simultaneous oral administration of rifampicin and other antibiotics with these sensitive strains is ineffective, development of new resistant mutants is desirable.