학술저널
공용 혼합물의 정제화에 관한 연구: 아스피린 및 이소푸로필안티피린 함유 정제의 제조
Tablet Formulation of Eutectic Mixture: Preparation of Tablet Containing Aspirin and Isopropylantipyrine
- 대한약학회
- 약학회지
- 제29권 제4호 (1985년)
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1985.08193 - 198 (6 pages)
- 71
In formulation technology, the drugs forming eutectic mixture cause many pharmaceutical problems. In this study, the method to prevent such problems has been investigated. The combined drugs of aspirin and isopropylantipyrine forming eutectic mixtures were granulated by using three kinds of binders (PVP, HPMC, starch) and these granules were made into pellets by compacting them with various compressional forces. It was possible to select optimum conditions in granulating, tableting, etc. Disintegration time and dissolution pattern were investigated about this formulation, too.
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