흰쥐에서 Merthiolate로 인한 수은의 체내 분포에 미치는 Sodium Selenite의 영향

Effects of Sodium Selenite on Merthiolate-induced Mercury Distribution in Rat

0.1%-Merthiolate solutions were applied to rats with or without sodium selenite. Rat organs were excised under ether anesthesia. Mercury contents in rat tissues were determined by quartz tube combustion gold amalgamation method. Mercury contents were accumulated at about 3-fold in the brain, 143-fold in the kidney, 62-fold in the blood cell, and 22-fold in the liver than those of untreated rats respectively, on the 1st day after application of merthiolate for 7 days. On the other hand, the addition of sodium selenite caused a shift in the tissue mercury distribution. Our study showed that simultaneous administration of sodium selenite increased the accumulation of mercury in the brain, but became to decrease it after 9 days, while decreased it in the kidney, but grew to increase it, respectively.