학술저널
새로운 beta-락탐계 화합물의 합성 및 항균성에 관한 연구
Synthesis and Antibacterial Activities of New beta-Lactam Compounds
- 대한약학회
- 약학회지
- 제30권 제1호 (1986년)
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1986.0224 - 30 (7 pages)
- 9
New antibiotics having moieties of penicillanic acid, cephalosporanic acid and ampicillin on both ends of the central alkylene were synthesized by reacting 6-aminopenicillanic acid (6-APA), 7-aminocephalosporanic acid (7-ACA) and ampicillin with hexamethylene diisocyanate and sebacoyl chloride, respectively. Antibacterial activities of the compounds were also investigated. The compound derived from sabacic acid and ampicillin exhibited an enhanced antibacterial activities against gram-negative bacteria and was found to be a promising wide-spectrum antibiotic.
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