학술저널
적출한 흰쥐 대동맥에 있어서 postsynaptic alpha1-, alpha2- 아드레날린 수용체에 관한 연구
Postsynaptic alpha1- and alpha2-Adrenoceptors in Rat Isolated Aorta
- 대한약학회
- 약학회지
- 제30권 제3호 (1986년)
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1986.06157 - 162 (6 pages)
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alpha-Adrenoceptor subtypes in the isolated rat aortic strips were examined by using agonists and antagonists which have varying selectivity for alpha1- and alpha2-adrenoceptors. Norepinephrine and phenylephrine produced a similar magnitude of maximum contractions. pA2 values for prazosin and yohimbine were not significantly different using norepinephrine or phenylephrine as the agonist, suggesting a single population of alpha-adrenoceptor. Contractile responses produced by alpha-agonists were antagonized more effectively by prazosin (approximately 1000 fold) than by yohimbine.
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