피페린 유도체의 합성 및 중추 억제작용에 관한 연구(V) -Methylenedioxyphenylalkenoic Acid Amide 유도체-

Syntheses and Central Nervous Depressant Activities of Piperine Derivatives(V) -Methylenedioxyphenylalkenoic Acid Amides-

Thirteen compounds were synthesized by condensing the N-heterocyclic amines (piperidine, pyrrolidine, morpholine) and secondary aliphatic amines (dimethylamine, diethylamine) with 3,4-methylenedioxyphenylalkenoic acid chlorides for developing CNS depressants. Among them, N,N-diethyl-3,4-methylenedioxycinnamamide (IX) and N,N-dimethyl-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid amide (XII) exhibited strong activity in antagonism against pentylenetetrazole-induced convulsion, strychnine-induced convulsion and maximal electroshock seizure. N,N-Dimethyl-3,4-methylenedioxycinnamide (VIII) showed more potent activity in antagonism against strychnine-induced convulsion and maximal electroshock seizure and in the prolongation of hexobarbital sleeping time.