학술저널
Piperine의 진통작용 기전에 관한 연구
A Study on the Mechanism of Analgesic Action of Piperine
- 대한약학회
- 약학회지
- 제30권 제4호 (1986년)
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1986.08169 - 173 (5 pages)
- 3
It was carried out to detect the analgesic action of piperine by hot-plate method and to elucidate its mechanism in rats. Piperine (30mg/kg i.p.) produced profound analgesia, which was blocked by naloxone (10mg/kg). Chronic intraperitoneal administration of piperine significantly increased the contents of beta-endorphin in rat midbrain. In the chronic piperine-treated groups, significant decreases of maximum opiate binding were observed. However, Kd value in these groups were not changed.
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