리팜피신과 이소니아짓의 약물상호작용

Drug Interaction of Rifampicin and Isoniazid

Rifampicin suspension was administered orally at a does of 34mg/kg to six rabbits after 5, 10 and 20mg/kg pretreatment of isoniazid twice daily for 9 days. The blood level of rifampicin was decreased significantly by isoniazid 10mg/kg, 20mg/kg pretreatment. The renal clearance(CLr) of rifampicin was increased by isoniazid 20mg/kg and the biliary clearance(CLb) was increased by isoniazid 10mg/kg and 20mg/kg pretreatment. Elimination rate constant(K) and time to reach maximum concentration(tmax) were increased by isoniazid pretreatment. But half-life and maximum concentration(Cmax) were decreased. Relative bioavailability was decreased significantly by isoniazid 10mg/kg and 20mg/kg pretreatment.