학술저널
수용액중 미녹시딜의 안정성
Stability of Minoxidil in Aqueous Solution
- 대한약학회
- 약학회지
- 제30권 제5호 (1986년)
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1986.10228 - 231 (4 pages)
- 22
The effect of temperature and pH on the degradation of minoxidil in the aqueous solution was investigated and the stability of pharmaceutical preparation for solution was also studied. The degradation of minoxidil in the aqueous solution was first order type reaction and the rate constant at 20oC in pH 7.0 phosphate buffer solution was 9.464 X 10-3day-1 and calculated activation energy was 11.7kcal/mol. The degradation of minoxidil was acid-base catalytic reaction and the most stable range of pH was about 5.0. The liquid pharmaceutical preparation was very stable in 3 months.
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