학술저널
beta-락탐계 항생물질의 폴리아크릴산 중합체의 합성 및 항균성
Synthesis and Antibiotic Activities of Poly(acrylic acid) Modified beta-Lactam Cyclics
- 대한약학회
- 약학회지
- 제30권 제5호 (1986년)
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1986.10232 - 238 (7 pages)
- 4
A series of modified poly(acrylic acid)''s containing different levels of 6-aminopenicillanic acid (6-APA), 7-aminocephalosporanic acid (7-ACA) and 6-[D-(-)-alpha-aminophenyl acetamido]penicillanic acid (ampicillin) as pendant groups were prepared. Antibiotic activities of the newly prepared drugs were examined against the various gram-positive and gram-negative bacteria. It was found that ampicillin modified composition posses antibiotic activities against the gram-negative as well as the gram-positive bacteria.
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