학술저널
Higenamine 유도체들의 혈소판응집 억제작용
Platelet Anti-aggregating Activities of Higenamine Analogs
- 대한약학회
- 약학회지
- 제30권 제5호 (1986년)
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1986.10245 - 252 (8 pages)
- 10
Various structural analogs of higenamine, 1-(4''-hydroxylbenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, were synthesized and their inhibitory activities against platelet aggregation induced by either arachidonic acid, ADP or collagen. Among the twenty-five compounds tested, inhibitory activity is favored by the 3,4-dihydroisoquinoline system with the methyl bridge between the two aromatic rings replaced by either ethyl or ethenyl group. N-Methyl quaternization decreased the inhibitory activities.
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