그리세오풀빈-페노바르비탈 상호작용(I) -페노바르비탈 전처리 Rat에 있어서 그리세오풀빈의 생체내 동태-

Griseofulvin-Phenobarbital Interaction(I) -Pharmacokinetics of Griseofulvin in Phenobarbital-pretreated Rats-

Effects of phenobarbital on the pharmacokinetics of griseofulvin were studied in rats. Phenobarbital was administered orally for five days at the dose of 75mg/kg/day. Absolute bioavaiability of oral griseofulvin was significantly(p<0.005) reduced but total clearance(CLs) was not changed by phenobarbital pretreatment. Absorption rate constant(Ka) and maximum plasma concentration(Cmax) were significantly(pmax) of griseofulvin was significantly(p<0.05) increased by phenobarbital pretreatment. Changed pharmacokinetics of griseofulvin seemed not to be due to induced enzyme activity by phenobarbital but to reduced GI absorption of griseofulvin.