학술저널
항암성 물질 Psorospermin의 합성중간체인 6-[3-(Hydroxymethyl)-2,3-epoxybutyl]-3,5-dimethoxyphenol의 합성
Synthesis of 6-[3-(Hydroxymethyl)-2,3-epoxybutyl]-3,5-dimethoxyphenol for the Preparation of Psorospermin
- 대한약학회
- 약학회지
- 제30권 제6호 (1986년)
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1986.12329 - 333 (5 pages)
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6-[3-(Hydroxymethyl)-2,3-epoxybutyl]-3,5-dimethoxyphenol was synthesized by means of the eight steps, such as allylether, Claissen rearrangement, tosylation, oxidation, Wittig reaction, reduction and epoxidation from 3,5-dimethoxyphenol. The epoxidation of 6-[3-(hydroxymethyl)-2-butenyl]-3,5-dimethoxy phenol using the L-(+)-diethyltartrate(DET), titanium(IV) isopropoxide Ti[(O-iPr)4] and t-butylhydroperoxide(TBHP) is described.
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