개의 신장기능에 미치는 메톡시베라파밀의 영향

Effect of Methoxyverapamil on Renal Function of Dogs

Methoxyverapamil, Ca2+ channel blocker, when given intravenously by means of bolus, produced the transient increase of urine flow, and then methoxyverapamil was infused in this experiments. Methyoxyverapamil, when infused into vein, elicited the increase of urine flow ancampanied with the increased glomeralar filtration rate(GFR), renal plasma flow(RPF), excretion amounts of sodium and potassium in urine(ENa, Ek) and osmolar clearance(Cosm), whereas produced the no change of free water clearance (CH2O) and the reduction of reabsorption rates of sodium and potassium in renal tubules(RNa, Rk). Methoxyverapamil, when infused into a renal artery, exhibited the diuretic action in only infused Kidney, at this time changes of renal function were the same aspect to that of intravenously infused methoxyverapamil. Methoxyverapamil, when infused into a carotid artery, exhibited the decreased urine flow along with the reduction of Cosm, CH2O) and ENa. Above results suggest that methoxyverapamil possess both the diuretic action by direct action in kidney and antidiuretic action through the central function.