1,4-나프로퀴논 유도체의 항균 및 항진균 작용

Antibacterial and Antifungal Activities of 1,4-Naphthoquinone Derivatives

In order to evaluate the antimicrobial effect of 2,3-substituted-1,4-naphthoquinone derivatives, we newly synthesized several 2-chloro, 2-bromo and 2-hydroxy-1,4-naphthoquinones and subjected to antibacterial and antifungal activities, in vitro, against Escherichia coli HIHJ, Staphylococcus aureus ATCC6538p, Candida albicans 10231, Aspergillus niger 1231 andTricophyton mentagrophytes 6085. Among these derivatives 3,9,18 and 23 showed the potent antibacterial activities. 18,23 and 28 have the antifungal activities. However, these compounds have no significant hemolytic activity at concentrations higher than that required for showing the antibacterial and antifungal activities.