학술저널
4-비페닐아세트산(펠비낙)의 합성
Facile Synthesis of 4-Biphenylacetic Acid (Felbinac)
- 대한약학회
- 약학회지
- 제36권 제2호 (1992년)
-
1992.04126 - 128 (3 pages)
- 0
A new method for felbinac, which is a potent anti-inflammatory agent, is described. Friedel-Crafts reaction of biphenyl with ethyl alpha-chloro-alpha-(methylthio)acetate(1) afforded ethyl 2-methylthio-2-(4-biphenylyl)acetate(4). Felbinac (7) was synthesized by desulfurization of compound (4) with zinc dust in acetic acid, followed by hydrolysis of the resultant ethyl 2-(4-biphenylyl)acetate(6).
(0)
(0)